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ATCC enterococcus faecalis atcc 29212 vancomycin sensitive enterococcus faecium atcc 700221 vre
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MIC/MBC ( μ M) Values a of Group 3 Analogues with Trialkyl- or Triaryl-phosphine Ligands
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MIC/MBC ( μ M) Values a of Group 3 Analogues with Trialkyl- or Triaryl-phosphine Ligands
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MIC/MBC ( μ M) Values a of Group 3 Analogues with Trialkyl- or Triaryl-phosphine Ligands

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Structure–Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens

doi: 10.1021/acs.jmedchem.9b00550

Figure Lengend Snippet: MIC/MBC ( μ M) Values a of Group 3 Analogues with Trialkyl- or Triaryl-phosphine Ligands

Article Snippet: 18 , 43 , 44 , 47 , 48 , 59 , 60 table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 A. baumannii NCTC 13420 P. aeruginosa NCTC 13437 E. cloacae NCTC 13405 K. pneumoniae ATCC 700603 S. aureus JE2 (USA300) E.faecium ATCC 700221 E. coli ATCC 25922 log P 1 47 (47) 377 (377) 189 (189) 377 (377) 0.04 (0.09) 0.2/0.09 (0.4) 24 (24) 0.56 2 47 (94) 377 (377) 377 (377) >377 0.04 (0.09) 0.2/0.4 (0.4) 24 (24) 0.38 24 (47) 189 (189) 47 (94) 189 (189) 0.04/0.09 (0.09) 0.09 (0.4) 12 (12) 0.26 4 f 82 (164) >328 >328 >328 0.01 (0.01) 0.08 (0.2) 21 (21) 1.01 5 f 33 (33) 132 (132) 66 (66) >265 0.008 (0.06) 0.03/0.06 (0.1) 17 (17) 0.45 6 g 66 (132) 132 (132) 265 (265) >265 0.03 (0.1) 0.1 (0.3) 33 (33) 1.04 7 c 12 (12) >194 24 (24) >194 0.003/0.006 (0.006) 0.05 (0.09) 24 (24) −0.28 8 f 76/19 (19) >303 152 (303) >303 0.04/0.009 (0.1) 0.04/0.07 (0.3) 152/323 (152) −0.36 9 63/16 (251) 502 (502) 125 (125) 502 (502) 0.06/0.1 (0.5) 0.1 (2) 31 (31) −0.81 10 31 (31) 251 (251) 63 (63) 251 (251) 0.02 (0.1) 0.1/0.2 (0.5) 16 (16) −0.73 11 31 (63) 502 (502) 125 (251) 502 (502) 0.02/0.06 (0.1) 0.1/0.06 (0.5) 16 (16) −0.59 12 15/29 (116) 464 (464) 116 (232) 464 (464) 0.02 (0.05) 0.05/0.1 (0.5) 7/4 (7) −0.89 13 24/48 (190) 381 (381) 190 (190) 381 (381) 0.02/0.05 (0.09) 0.09 (0.4) 24 (24) −1.81 14 24 (24) 381 (381) 190 (190) >381 0.09/0.04 (0.09) 0.09/0.2 (0.4) 12 (12) −1.69 Open in a separate window a Assays were repeated twice.

Techniques:

MIC/MBC ( μ M) Values a of Group 2 Analogues with Aromatic or Aliphatic Thiol Ligands

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Structure–Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens

doi: 10.1021/acs.jmedchem.9b00550

Figure Lengend Snippet: MIC/MBC ( μ M) Values a of Group 2 Analogues with Aromatic or Aliphatic Thiol Ligands

Article Snippet: 18 , 43 , 44 , 47 , 48 , 59 , 60 table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 A. baumannii NCTC 13420 P. aeruginosa NCTC 13437 E. cloacae NCTC 13405 K. pneumoniae ATCC 700603 S. aureus JE2 (USA300) E.faecium ATCC 700221 E. coli ATCC 25922 log P 1 47 (47) 377 (377) 189 (189) 377 (377) 0.04 (0.09) 0.2/0.09 (0.4) 24 (24) 0.56 2 47 (94) 377 (377) 377 (377) >377 0.04 (0.09) 0.2/0.4 (0.4) 24 (24) 0.38 24 (47) 189 (189) 47 (94) 189 (189) 0.04/0.09 (0.09) 0.09 (0.4) 12 (12) 0.26 4 f 82 (164) >328 >328 >328 0.01 (0.01) 0.08 (0.2) 21 (21) 1.01 5 f 33 (33) 132 (132) 66 (66) >265 0.008 (0.06) 0.03/0.06 (0.1) 17 (17) 0.45 6 g 66 (132) 132 (132) 265 (265) >265 0.03 (0.1) 0.1 (0.3) 33 (33) 1.04 7 c 12 (12) >194 24 (24) >194 0.003/0.006 (0.006) 0.05 (0.09) 24 (24) −0.28 8 f 76/19 (19) >303 152 (303) >303 0.04/0.009 (0.1) 0.04/0.07 (0.3) 152/323 (152) −0.36 9 63/16 (251) 502 (502) 125 (125) 502 (502) 0.06/0.1 (0.5) 0.1 (2) 31 (31) −0.81 10 31 (31) 251 (251) 63 (63) 251 (251) 0.02 (0.1) 0.1/0.2 (0.5) 16 (16) −0.73 11 31 (63) 502 (502) 125 (251) 502 (502) 0.02/0.06 (0.1) 0.1/0.06 (0.5) 16 (16) −0.59 12 15/29 (116) 464 (464) 116 (232) 464 (464) 0.02 (0.05) 0.05/0.1 (0.5) 7/4 (7) −0.89 13 24/48 (190) 381 (381) 190 (190) 381 (381) 0.02/0.05 (0.09) 0.09 (0.4) 24 (24) −1.81 14 24 (24) 381 (381) 190 (190) >381 0.09/0.04 (0.09) 0.09/0.2 (0.4) 12 (12) −1.69 Open in a separate window a Assays were repeated twice.

Techniques:

MIC/MBC ( μ M) Values a of Analogues with Trimethylphosphine Ligands

Journal: Journal of medicinal chemistry

Article Title: Synthesis and Structure–Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens

doi: 10.1021/acs.jmedchem.9b00550

Figure Lengend Snippet: MIC/MBC ( μ M) Values a of Analogues with Trimethylphosphine Ligands

Article Snippet: 18 , 43 , 44 , 47 , 48 , 59 , 60 table ft1 table-wrap mode="anchored" t5 Table 1. caption a7 A. baumannii NCTC 13420 P. aeruginosa NCTC 13437 E. cloacae NCTC 13405 K. pneumoniae ATCC 700603 S. aureus JE2 (USA300) E.faecium ATCC 700221 E. coli ATCC 25922 log P 1 47 (47) 377 (377) 189 (189) 377 (377) 0.04 (0.09) 0.2/0.09 (0.4) 24 (24) 0.56 2 47 (94) 377 (377) 377 (377) >377 0.04 (0.09) 0.2/0.4 (0.4) 24 (24) 0.38 24 (47) 189 (189) 47 (94) 189 (189) 0.04/0.09 (0.09) 0.09 (0.4) 12 (12) 0.26 4 f 82 (164) >328 >328 >328 0.01 (0.01) 0.08 (0.2) 21 (21) 1.01 5 f 33 (33) 132 (132) 66 (66) >265 0.008 (0.06) 0.03/0.06 (0.1) 17 (17) 0.45 6 g 66 (132) 132 (132) 265 (265) >265 0.03 (0.1) 0.1 (0.3) 33 (33) 1.04 7 c 12 (12) >194 24 (24) >194 0.003/0.006 (0.006) 0.05 (0.09) 24 (24) −0.28 8 f 76/19 (19) >303 152 (303) >303 0.04/0.009 (0.1) 0.04/0.07 (0.3) 152/323 (152) −0.36 9 63/16 (251) 502 (502) 125 (125) 502 (502) 0.06/0.1 (0.5) 0.1 (2) 31 (31) −0.81 10 31 (31) 251 (251) 63 (63) 251 (251) 0.02 (0.1) 0.1/0.2 (0.5) 16 (16) −0.73 11 31 (63) 502 (502) 125 (251) 502 (502) 0.02/0.06 (0.1) 0.1/0.06 (0.5) 16 (16) −0.59 12 15/29 (116) 464 (464) 116 (232) 464 (464) 0.02 (0.05) 0.05/0.1 (0.5) 7/4 (7) −0.89 13 24/48 (190) 381 (381) 190 (190) 381 (381) 0.02/0.05 (0.09) 0.09 (0.4) 24 (24) −1.81 14 24 (24) 381 (381) 190 (190) >381 0.09/0.04 (0.09) 0.09/0.2 (0.4) 12 (12) −1.69 Open in a separate window a Assays were repeated twice.

Techniques: